Hair Growth Miracle: UCLA’s PP405 Cures Baldness or Hype? (2025)
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Researchers studying genetics at UCLA are reviving ( Hair Growth ) dormant follicles.
With encouraging early trial findings, a chemical found at UCLA called PP405 may finally give people hope for hair regeneration by reviving dormant follicles.
Ancient Egyptians used a concoction of dates, dog paw, and donkey foot to massage their bald heads; Celtic healers used mice in a jar.
Yucca juice became popular among Native Americans. There have been several existential quests throughout human history, including those for wealth, wisdom, peace, and a remedy for baldness.
Numerous causes, such as aging, stress, hormonal imbalances, and bad genetics, can contribute to hair loss.
Few treatments have worked for more than one in three people despite medical advancements, forcing many to try dubious treatments or endure costly procedures.
For those who are folli-cally challenged, the medications Rogaine and Propecia have given them hope, but even bigger discoveries might be coming.
Researchers at UCLA have now discovered a tiny chemical that can awaken long-slumbering but unharmed follicles when stimulated.
The carrying molecule has been named “PP405” by the researchers, maybe in reference to the 405 freeway, another annoyance that inhabitants of Los Angeles must endure.
Maybe everyone will soon have a full head of hair.
According to science, a protein in follicular stem cells that maintains the cells quiescent is bound by the isolated PP405 molecule.
The protein is inhibited as a result, causing the stem cells to awaken. The molecule has been the subject of laboratory research for nearly ten years.
Researchers observed that applying PP405, a topical medication, to the scalp at night for a week had encouraging effects in the first human studies, which were carried out in 2023.
The UCLA researchers characterized the findings as “statistically significant,” despite their caution with real data.
Above all, they think the therapy will result in complete “terminal” hair instead of the peach fuzz type that other modern miracle-cure lotions and potions produce.
The three UCLA scientists who made the discovery, Michael Jung, distinguished professor of chemistry.
Heather Christofk ’01, professor of biological chemistry; and William Lowry, professor of molecular, cell, and developmental biology, are optimistic about
the treatment’s ability to reverse pattern hair loss, which affects one-fourth of women and more than half of men by the age of 50.
Lowry, who is currently lavishly coiffed, acknowledges that hair loss is likely to occur in the future.
“Most men and women suffer from thinning hair at some point, or lose it after chemotherapy, infections, or other stressors, and it affects them psychologically,” he adds.
Trials and approvals are the next steps.
Or perhaps not. “No such product will work for everyone,” he adds, adding that “larger trials with more people to follow have been very encouraging from our first human trials in Orange County.”
“But we were happy to be wrong about that,” adds Lowry, who and his team were worried that the PP405 tiny chemical may kill all of the follicles.
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Through UCLA’s Technology Transfer Group, which turns innovative research into products for the global market, the scientists have co-founded Pelage Pharmaceuticals, a medical development firm.
Supported by Google Ventures, the business raised $16.4 million last year to support additional trials and obtain regulatory approvals.
According to Lowry, “FDA approvals always take some time, as they should.” “But the wait will be worthwhile.”